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Recombinant Clostridium difficile Toxin B (tcdB), N-His-SUMO

Cat. No.VG3F253

Product TypeVeterinary Antigens

Size

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Product Overview

BioVenic's Recombinant Clostridium difficile Toxin B (tcdB), N-His-SUMO is a recombinant protein expressed from E.coli Expression System. Its predicted molecular weight is 43.1kDa. The purity is>90% (SDS-PAGE).

Specifications

Type Recombinant Protein
Species Bacteria
Expression System E.coli Expression System
Purity >90% (SDS-PAGE)
Predicted Molecular Weight 43.1kDa
Physical State Lyophilized
Formulation PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Target Information

TcdB is a potent exotoxin and primary virulence factor of Clostridioides difficile. It functions as a glucosyltransferase that targets and inactivates Rho-family GTPases (Rho, Rac, and Cdc42) within the host cell cytoplasm. This disruption leads to actin cytoskeleton reorganization, massive cell rounding (cytopathic effect), and eventual apoptosis. As a critical driver of antibiotic-associated diarrhea and pseudomembranous colitis, TcdB is a major focus for neutralizing antibody therapies and vaccine development.

Protein Clostridium difficile Toxin B (tcdB)
Protein Synonym Toxin B; Cytotoxin; Cytopathic toxin; Enterotoxin B; TcdB1
UniProt ID P18177

Shipping and Storage

This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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User Note

  1. Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.
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