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Recombinant Clostridium difficile Toxin A (tcdA), N-His
Product Overview
BioVenic's Recombinant Clostridium difficile Toxin A (tcdA), N-His is a recombinant protein expressed from E.coli Expression System. Its predicted molecular weight is 16.5 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
TcdA is a high-molecular-weight enterotoxin produced by Clostridioides difficile. It primarily targets the intestinal epithelium, binding to apical carbohydrates to trigger its internalization. Once inside the cytosol, it monoglucosylates Rho-family GTPases, leading to the breakdown of tight junctions, increased vascular permeability, and extensive mucosal inflammation. While similar to TcdB, TcdA is specifically noted for its potent proinflammatory activity and its role in the early stages of fluid secretion and tissue damage during C. difficile infection (CDI).
Shipping and Storage
This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.