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Recombinant Clostridium botulinum Botulinum Neurotoxin Type A, C-His
Product Overview
BioVenic's Recombinant Clostridium botulinum Botulinum Neurotoxin Type A, C-His is a recombinant protein expressed from E.coli Expression System. Its predicted molecular weight is 49.6 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Botulinum Neurotoxin Type A is one of the most poisonous biological substances known. It is produced as a progenitor complex and processed into a dichain consisting of a Heavy Chain (HC) and a Light Chain (LC) linked by a disulfide bond. The HC mediates highly specific binding to neuronal receptors and translocation, while the LC acts as a zinc-dependent endopeptidase. It specifically cleaves SNAP-25, a SNARE protein essential for acetylcholine release at neuromuscular junctions, leading to flaccid paralysis and its well-known therapeutic and cosmetic applications.
Shipping and Storage
This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.