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Recombinant Chicken Zinc Finger Protein GLI2 (GLI2)
Product Overview
BioVenic's Recombinant Chicken Zinc Finger Protein GLI2 (GLI2) is a recombinant protein expressed from E.coli. Its predicted molecular weight is 73.1 kDa. The purity is>85% (SDS-PAGE).
Specifications
Target Information
Chicken Zinc Finger Protein GLI2 (GLI2) is a transcription factor that plays a crucial role in the Hedgehog signaling pathway, essential for embryonic development and tissue homeostasis. GLI2 contains multiple zinc finger motifs and regulates gene expression, particularly promoting the transcription of genes involved in cell proliferation, differentiation, and survival. In chickens, GLI2 is highly expressed in developing tissues, aiding in the formation of structures like limbs and the nervous system. Abnormal GLI2 expression or function is linked to various cancers, including gastric cancer, where it can enhance tumor growth and metastasis through chemoresistance and epithelial-mesenchymal transition (EMT).
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in deionized sterile water to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.