Recombinant Chicken Zinc Finger Protein GLI1 (GLI1)

Chicken Zinc Finger Protein GLI1 (GLI1) is a transcription factor that plays a crucial role in the Hedgehog signaling pathway, which is essential for embryonic development and tissue homeostasis. GLI1 contains multiple zinc finger motifs and a KRAB domain, which are critical for DNA binding and transcriptional regulation. It acts as a nuclear mediator of Hedgehog signaling, activating the transcription of target genes involved in cell proliferation, differentiation, and survival. In chickens, GLI1 is highly expressed in developing tissues, where it regulates the formation of various structures, including limbs and the nervous system. Abnormal activation of GLI1 has been implicated in various cancers, including glioma and osteosarcoma, where it promotes tumor growth and metastasis.