Recombinant Chicken Zinc Finger E-box-Binding Homeobox 1 (ZEB1)

Chicken Zinc Finger E-box-Binding Homeobox 1 (ZEB1) is a transcription factor that plays a crucial role in epithelial-to-mesenchymal transition (EMT) during embryogenesis and tissue repair. It binds to specific E-box sequences in the promoters of target genes, regulating their expression. ZEB1 can act as both a transcriptional activator and repressor, depending on the context. In chickens, ZEB1 is involved in various developmental processes and has been implicated in immune regulation and cancer progression. Abnormal expression of ZEB1 has been associated with diseases such as cancer, where it promotes tumor invasion and metastasis by inducing EMT. Additionally, ZEB1 is involved in the regulation of metabolic pathways, such as serine synthesis, which can contribute to cancer development. Its dual role in promoting cell plasticity and maintaining tissue homeostasis highlights its importance in both normal development and disease.