Recombinant Chicken Muscarinic Acetylcholine Receptor M2 (CHRM2)

Chicken Muscarinic Acetylcholine Receptor M2 (CHRM2) is a G protein-coupled receptor (GPCR) that plays a crucial role in modulating neuronal excitability, synaptic plasticity, and the release of acetylcholine. It is primarily coupled to Gi/o proteins, which inhibit adenylate cyclase and reduce intracellular cAMP levels. This receptor is widely expressed in the central nervous system, particularly in regions such as the brainstem, thalamus, cortex, hippocampus, and striatum, where it helps control acetylcholine release and modulate various cognitive and motor functions. In chickens, CHRM2 is likely involved in similar functions, influencing neural signaling and behavior. Abnormalities in CHRM2 function have been implicated in several neurological disorders, including Alzheimer's disease, schizophrenia, and depression. Additionally, CHRM2 plays a role in the autonomic nervous system, mediating effects such as reduced heart rate and increased digestive secretions.