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Recombinant Chicken GTP Cyclohydrolase 1 (GCH1)
Product Overview
BioVenic's Recombinant Chicken GTP Cyclohydrolase 1 (GCH1) is a recombinant protein expressed from E.coli. Its predicted molecular weight is 26.1 kDa. The purity is>85% (SDS-PAGE).
Specifications
Target Information
Chicken GTP Cyclohydrolase 1 (GCH1) is a key enzyme that catalyzes the first and rate-limiting step in the synthesis of tetrahydrobiopterin (BH4), a crucial cofactor for aromatic amino acid hydroxylases and nitric oxide synthase. BH4 is essential for the production of neurotransmitters and the regulation of blood pressure. In chickens, GCH1 plays a significant role in maintaining cellular redox balance and protecting cells from oxidative stress. It is also involved in the regulation of immune responses and has been implicated in the pathogenesis of neurodegenerative diseases. Abnormal expression of GCH1 can lead to conditions such as hypertension and diabetes, highlighting its importance in metabolic and cardiovascular health.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in deionized sterile water to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.