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Recombinant Canine Receptor Protein-Tyrosine Kinase (ERBB2), N-His
Product Overview
BioVenic's Recombinant Canine Receptor Protein-Tyrosine Kinase (ERBB2), N-His is a recombinant protein expressed from E.coli Expression System. Its predicted molecular weight is 37.4 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Canine CD340 (ERBB2) is a receptor tyrosine kinase and a member of the epidermal growth factor receptor (EGFR) family. Unlike other members, it lacks a direct ligand-binding domain and functions primarily through heterodimerization with other ligand-bound ErbB receptors. This process activates critical downstream pathways, including PI3K/Akt and MAPK, to regulate cell growth and survival. Overexpressed in many canine cancers-notably mammary carcinomas, osteosarcomas, and bladder tumors-it is a vital biomarker for targeted therapy and comparative oncology research.
Shipping and Storage
This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.