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Recombinant Canine Neuregulin-1 (NRG1)
Product Overview
BioVenic's Recombinant Canine Neuregulin-1 (NRG1) is a recombinant protein expressed from E. coli expression system. Its predicted molecular weight is 8 kDa. The purity is greater than 95% (SDS-PAGE). The endotoxin level is <1 EU/μg (LAL).
Specifications
Target Information
Neuregulin 1 is encoded by the NRG1 gene in dogs. NRG1 is widely distributed throughout the central and peripheral nervous systems. Neuregulin 1 is produced in numerous isoforms by alternative splicing, allowing it to perform a variety of functions. NRG1 directs ligand for the ERBB3 and ERBB4 tyrosine kinase receptors, simultaneously recruiting ERBB1 and ERBB2 coreceptors, leading to ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquote as needed and store at -20°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -20°C for 3 months.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Dissolve the lyophilized protein in distilled water. Avoid mixing by vortexing or pipetting. It is not recommended to reconstitute to a concentration < 100 μg/mL. Aliquote the reconstituted solution to minimise freeze-thaw cycles.
References
- Zhou, X. et al. Regulation of the NRG1/ErbB4 pathway in the intrinsic cardiac nervous system is a potential treatment for atrial fibrillation. Frontiers in physiology. 2018, 9: 1082.