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Recombinant Canine Lymphocyte Activating 3 (LAG3), C-His

Product Overview

BioVenic's Recombinant Canine Lymphocyte Activating 3 (LAG3), C-His is a recombinant protein expressed from HEK293 Cells. Its predicted molecular weight is 46.8 kDa. The purity is>95% (SDS-PAGE). The endotoxin level is <1 EU/μg (LAL).

Specifications

Type Recombinant Protein

Species Canine

Expression System HEK293 Cells

Purity >95% (SDS-PAGE)

Endotoxin <1 EU/μg (LAL)

Predicted Molecular Weight 46.8 kDa

Physical State Lyophilized

Formulation PBS, pH 7.4, with trehalose.

Target Information

Lymphocyte activating 3 is encoded by the LAG3 gene in dogs. It has emerged as an eminent target in the development of cancer treatment and holds substantial prognostic value. LAG-3 is closely related to CD4, with which it shares the ability to bind MHC class II molecules.

Protein Canine Lymphocyte Activating 3 (LAG3)

Protein Synonym lymphocyte activating 3, lymphocyte activation gene 3 protein, lymphocyte-activation gene 3

Gene ID 486720

Shipping and Storage

This product is shipped with dry ice. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

User Note

Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.

References

Lecocq, Q. et al. The next-generation immune checkpoint LAG-3 and its therapeutic potential in oncology: Third time's a charm. International journal of molecular sciences. 2020, 22: 1867.