This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Recombinant Bovine Polymeric Immunoglobulin Receptor (PIGR)
Product Overview
BioVenic's Recombinant Bovine Polymeric Immunoglobulin Receptor (PIGR) is a recombinant protein expressed from E.coli. Its predicted molecular weight is 13.2 kDa. The purity is>95% (SDS-PAGE).
Specifications
Target Information
Bovine polymeric immunoglobulin receptor (PIGR) is a transmembrane glycoprotein that plays a crucial role in mucosal immunity by facilitating the transport of polymeric immunoglobulins, such as IgA and IgM, across mucosal epithelial cells. It is composed of an N-terminal ligand-binding domain, a single membrane-spanning region, and a short cytoplasmic C-terminal tail. In Bovine, PIGR is essential for the secretion of antibodies into mucosal surfaces, providing a first line of defense against pathogens by promoting the formation of secretory immunoglobulins like secretory IgA (SIgA). This process is vital for maintaining mucosal barrier integrity and preventing infections.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquot as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimise freeze-thaw cycles.