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Recombinant Bovine Melatonin Receptor Type 1A (MTNR1A), N-His
Product Overview
BioVenic's Recombinant Bovine Melatonin Receptor Type 1A (MTNR1A), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 16.6 kDa. The purity is> 90%.
Specifications
Target Information
Bovine Melatonin Receptor Type 1A (MTNR1A) is a high-affinity receptor for melatonin, a hormone that regulates circadian rhythms and reproductive processes. MTNR1A mediates the effects of melatonin on bovine granulosa cells, influencing cellular progression, apoptosis, hormone secretion, and overall reproductive function. It is expressed in the ovaries, particularly in granulosa cells and oocytes, where it plays a role in follicle development and oocyte maturation. Melatonin, acting through MTNR1A, has been shown to inhibit apoptosis in granulosa cells by upregulating anti-apoptotic genes and downregulating pro-apoptotic genes. Additionally, MTNR1A is involved in modulating the secretion of hormones such as progesterone and estradiol, which are crucial for reproductive health. In bovine systems, MTNR1A is essential for mediating the reproductive and circadian actions of melatonin, highlighting its importance in both basic biological processes and potential applications in reproductive management.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.