Recombinant Bovine Major Surface Glycoprotein G (G), N-His

The respiratory syncytial virus (RSV) major surface glycoprotein G (G) in Bovines plays a crucial role in the initial stages of infection by interacting with heparan sulfate on the host cell membrane, which facilitates attachment and subsequent viral entry. Although G protein lacks neuraminidase and hemagglutinating activities, which are common in other paramyxoviruses, it is vital for virus attachment and immune evasion strategies. Moreover, the G protein contributes to the virus's ability to counteract host immune responses by acting as an antigenic decoy, thus hindering the effectiveness of antibody-dependent restrictions on viral replication. This immune modulation is significant for the virus's persistence and spread within the Bovine population. Furthermore, the G protein is a key target for vaccine development due to its role in viral attachment and immune response. Research into the G protein's structure and function is essential for understanding RSV pathogenesis in cattle and for developing effective control measures against Bovine respiratory diseases.