This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Recombinant Bovine Collagenase 3 (MMP13), N-His
Product Overview
BioVenic's Recombinant Bovine Collagenase 3 (MMP13), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 28.2 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Bovine matrix metalloproteinase 13 (MMP13), also known as collagenase-3, is a member of the matrix metalloproteinase family of enzymes. This protein is essential in cattle for the degradation of extracellular matrix components, particularly collagen types I, II, and III, which are crucial for bone and cartilage health. MMP13 plays a significant role in physiological processes such as tissue remodeling, wound healing, and the development of the skeletal system. It is highly expressed during embryogenesis and in adult bone during endochondral ossification. In the context of disease, MMP13 is implicated in the pathogenesis of conditions like osteoarthritis and is a key regulator in the activation of osteoclasts, which are important for bone resorption. The balanced expression and activity of MMP13 are vital for maintaining tissue homeostasis, and its dysregulation can lead to various pathological conditions in cattle.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquot as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimise freeze-thaw cycles.