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Rabbit Anti-Rat Transcobalamin II (TCN2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat transcobalamin II, macrocytic anemia. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat transcobalamin II, macrocytic anemia.
Specifications
Target Information
Rat transcobalamin II (TC-II) is a 428-residue secreted glycoprotein that binds vitamin B12 via a high-affinity pocket formed by two juxtaposed α/β domains stabilized by a calcium ion and three disulfide bridges. Synthesized primarily in liver and ileal enterocytes, the 43 kDa polypeptide circulates as a 1:1 holo-transporter complex protecting cobalamin from degradation and delivering it to TC-II receptors on dividing cells. Congenital deficiency produces macrocytic anemia through impaired DNA synthesis. Antibodies raised against recombinant rat TC-II recognize both apo- and holo-forms with negligible cross-reactivity to intrinsic factor, haptocorrin, or albumin, enabling direct quantification in rat plasma and tissue extracts.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.