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Rabbit Anti-Rat Thioredoxin Reductase 1 (TXNRD1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat thioredoxin reductase 1. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat thioredoxin reductase 1.
Specifications
Target Information
Rat thioredoxin reductase 1 (Txnrd1) is a 499-residue cytosolic selenoenzyme whose N-terminal FAD-binding domain and C-terminal redox center containing selenocysteine at position 498 catalyze NADPH-dependent reduction of thioredoxin and low-molecular-weight disulfides. The protein functions as a head-to-tail homodimer bridged by an intersubunit disulfide between Cys59 and Sec498, generating a flavin-selenide redox chain. Constitutively expressed in liver, lung and brain, the reductase localizes to cytosol and nucleus. Antibodies raised against full-length or Sec498-proximal peptides detect native, reduced and glutathionylated isoforms with negligible cross-reactivity to Txnrd2 or glutathione reductase, enabling selective immunoblot and immunohistochemical visualization in rat tissue homogenates and sections.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.