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Rabbit Anti-Rat T-Box Protein 21 (TBX21) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat T-box protein 21. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat T-box protein 21.
Specifications
Target Information
Rat T-box protein 21 (Tbx21, T-bet) is a 525-residue nuclear transcription factor whose N-terminal T-domain recognizes the consensus 5'-T(G/C)ACAC(T/A)(C/G)-3' via a helix-turn-helix motif anchored by a hydrophobic core. A proline-rich C-terminal tail recruits chromatin remodelers and is targeted by phosphorylation. Restricted to CD4⁺, CD8⁺ T cells, NK cells and dendritic cells, Tbx21 localizes to euchromatin during lineage specification. Antibodies raised against rat-specific T-domain or full-length protein detect native, phosphorylated and truncated isoforms with negligible cross-reactivity to other T-box family members, enabling selective immunoblot, immunohistochemistry and chromatin immunoprecipitation in rat lymphoid tissues and cultured immune cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.