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Rabbit Anti-Rat Pregnane X Receptor (PXR) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat pregnane X receptor. It is purified by Protein A Purified . It can be applied to WB, IHC, ICC and IP assays of rat pregnane X receptor.
Specifications
Target Information
Rat Pregnane X Receptor (PXR) is a nuclear receptor involved in the regulation of drug metabolism and detoxification. It is activated by a variety of xenobiotics, including drugs and environmental chemicals, and regulates the expression of genes involved in their metabolism and transport. PXR is highly expressed in the liver and intestines, where it plays a crucial role in maintaining metabolic homeostasis and protecting the body from toxic substances. Its activity is essential for the induction of cytochrome P450 enzymes and other detoxifying proteins. PXR is an important target for studying pharmacokinetics and drug-drug interactions in rat models.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Spruiell, Krisstonia, et al. "Role of pregnane X receptor in obesity and glucose homeostasis in male mice." Journal of Biological Chemistry 289.6 (2014): 3244-3261.