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Rabbit Anti-Rat Neurokinin B (NKB) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat neurokinin B. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat neurokinin B.
Specifications
Target Information
Rat neurokinin B (NKB) is a ten-amino-acid amidated peptide (Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH₂) derived from proteolytic cleavage of the 121-residue preprotachykinin B precursor. Four residues (Phe⁵-Phe⁶-Val⁷) create a hydrophobic core, while the C-terminal methioninamide confers high-affinity binding to the neurokinin 3 receptor. Expressed selectively in hypothalamic arcuate neurons and spinal interneurons, NKB is packaged into dense-core vesicles and co-released with kisspeptin. Antibodies raised against the full amidated decapeptide or C-terminal fragment detect native NKB with negligible cross-reactivity to substance P or neurokinin A, enabling precise immunohistochemical and immunoblot visualization in rat brain extracts and tissue sections.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.