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Rabbit Anti-Rat Kynurenine-3-Monooxygenase (KMO) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat kynurenine-3-monooxygenase. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat kynurenine-3-monooxygenase.
Specifications
Target Information
Rat kynurenine-3-monooxygenase (KMO) is a 58 kDa outer-mitochondrial flavoprotein whose FAD-binding pocket and flexible active-site lid convert kynurenine to 3-hydroxykynurenine, steering tryptophan catabolism. A solvent-exposed 14-aa "KVE" loop (aa 210-223) between the FAD and substrate domains folds into a β-hairpin unique among rat oxidoreductases, presenting a conformational epitope preserved after mitochondrial isolation and fixation. Affinity-purified antibodies targeting this loop trace native KMO in hepatic outer membranes, spinal microglia, and renal proximal tubules, delivering crisp punctate staining and single-band clarity on immunoblots with no cross-reaction to other kynurenine pathway enzymes.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.