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Rabbit Anti-Rat Intercellular Adhesion Molecule 2 (ICAM2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat intercellular adhesion molecule 2. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat intercellular adhesion molecule 2.
Specifications
Target Information
Rat intercellular adhesion molecule 2 (ICAM-2, CD102) is a 276-residue type I transmembrane glycoprotein whose two N-terminal Ig-like domains (D1-D2) bind the I-domain of integrin LFA-1 (αLβ2) and Mac-1 (αMβ2). A single transmembrane helix anchors the protein to endothelial and lymphocyte plasma membranes, while a short 27-aa cytoplasmic tail lacks signalling motifs but interacts with ezrin-radixin-moesin proteins. Constitutively expressed on vascular endothelium, platelets and dendritic cells, ICAM-2 localizes to tight junctions and microvilli. Antibodies raised against D1 or cytoplasmic peptide detect native, glycosylated and shed forms with negligible cross-reactivity to ICAM-1 or ICAM-3, enabling selective immunoblot and immunohistochemical visualization in rat tissue homogenates and sections.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.