This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Rabbit Anti-Rat Indoleamine-2,3-Dioxygenase (IDO) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat indoleamine-2,3-dioxygenase. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat indoleamine-2,3-dioxygenase.
Specifications
Target Information
Rat indoleamine-2,3-dioxygenase (IDO1) is a 45 kDa cytosolic heme enzyme whose N-terminal catalytic cleft oxidizes tryptophan to kynurenine, starving pathogens and suppressing T-cell proliferation. A solvent-exposed 14-aa "KVE" loop (aa 160-173) between the heme-binding helix and the substrate gate folds into a β-hairpin unique among rat oxidoreductases, presenting a conformational epitope preserved after fixation. Affinity-purified antibodies targeting this loop trace native IDO1 in activated macrophages, placental trophoblasts, and tumor-draining lymph nodes, delivering crisp cytoplasmic puncta and single-band clarity on immunoblots with no cross-reaction to IDO2 or TDO.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.