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Rabbit Anti-Rat GATA Binding Protein 1 (GATA1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat GATA binding protein 1. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat GATA binding protein 1.
Specifications
Target Information
Rat GATA-binding protein 1 (GATA1) is a 413-amino-acid nuclear transcription factor harboring tandem Cys-X2-Cys-X17-Cys-X2-Cys zinc fingers that bind (A/T)GATA(A/G) motifs; the N-terminal finger stabilizes DNA contact while the C-terminal finger confers sequence specificity and recruits FOG-1 cofactor. Expressed exclusively in erythroid, megakaryocytic, eosinophilic and mast cell lineages, the protein localizes to euchromatic nuclei during differentiation. Post-translational phosphorylation and acetylation modulate its trans-activation domain. Antibodies raised against full-length rat GATA1 or individual zinc-finger peptides detect native and modified isoforms with negligible cross-reactivity to GATA2-6, enabling selective immunoblot, immunohistochemistry and chromatin immunoprecipitation in rat hematopoietic tissues and cultured precursor cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.