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Rabbit Anti-Rat Cluster of Differentiation 146 (CD146) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat cluster of differentiation 146. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat cluster of differentiation 146.
Specifications
Target Information
Rat cluster of differentiation 146 (CD146) is a transmembrane glycoprotein of the immunoglobulin superfamily, a key mediator of cell adhesion and vascular homeostasis. It features three conserved extracellular Ig-like domains, a single transmembrane segment, and a cytoplasmic tail with phosphorylation motifs critical for structural integrity and signal transduction. It localizes to the cell membranes of rat vascular endothelial cells, smooth muscle cells and activated lymphocytes, with negligible levels in non-vascular and resting immune tissues. The protein mediates endothelial cell migration and leukocyte adhesion, with conserved motifs for binding to integrins and extracellular matrix components. Rat CD146 shares core functional domains with mammalian orthologs, and has distinct tissue specificity differentiating it from other adhesion molecules.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.