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Rabbit Anti-Rat Caldesmon (CALD) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat caldesmon. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat caldesmon.
Specifications
Target Information
Rat caldesmon (CaD) is a 89-kDa actin-binding protein widely expressed in rat smooth muscle tissues (vascular, gastrointestinal, uterine) and non-muscle cells (fibroblasts, epithelial cells). It regulates actin-myosin interaction: in smooth muscle, it inhibits contraction at low calcium levels and releases this inhibition upon calcium-calmodulin binding, enabling muscle tone control. In non-muscle cells, it stabilizes the cytoskeleton, supports cell migration, and modulates membrane protrusion. Abundant in rat tissues requiring mechanical flexibility or motility, it maintains cellular structure and tissue contractile function. As a key mediator of actin cytoskeleton dynamics and smooth muscle contraction, rat caldesmon is a critical target for studying vascular physiology, gastrointestinal motility disorders, and cytoskeleton-related cellular processes.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.