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Rabbit Anti-Rat B-Cell Activation Factor Receptor (BAFFR) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat B-cell activation factor receptor. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat B-cell activation factor receptor.
Specifications
Target Information
Rat B-cell activation factor receptor (BAFFR) is a transmembrane glycoprotein of the tumor necrosis factor receptor superfamily, a core regulator of B-cell survival, maturation and homeostasis. It features a conserved extracellular cysteine-rich domain for BAFF ligand binding, a single transmembrane segment, and a cytoplasmic tail critical for downstream signal transduction. It localizes predominantly to the plasma membrane of rat B lymphocytes at various developmental stages, with negligible expression in T cells and non-immune tissues. The protein mediates NF-κB pathway activation, with conserved motifs for recruiting adaptor proteins. Rat BAFFR shares core functional domains with mammalian orthologs, and has distinct B-cell specificity differentiating it from TACI and BCMA.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.