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Rabbit Anti-Rat Axis Inhibition Protein (AXIN) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat axis inhibition protein. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat axis inhibition protein.
Specifications
Target Information
Rat axis inhibition protein 1 (Axin1) is an 86 kDa scaffold whose N-terminal RGS domain captures APC while a C-terminal DIX segment polymerizes with Dishevelled, nucleating the β-catenin destruction complex. A solvent-exposed 16-aa "KVE" loop (aa 380-395) between GSK3β- and β-catenin-binding sites folds into a β-hairpin unique among rat Axin paralogs, presenting a conformational epitope preserved after phosphorylation and fixation. Antibodies targeting this loop trace native Axin1 in hepatic cytoplasm, colonic crypts, and neuronal growth cones, delivering crisp punctate staining and single-band clarity on immunoblots with no cross-reaction to Axin2.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.