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Rabbit Anti-Rat Angiostatin (ANG) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat angiostatin. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat angiostatin.
Specifications
Target Information
Rat angiostatin (ANG) is a secreted proteolytic fragment of plasminogen, a potent endogenous inhibitor of angiogenesis and endothelial cell proliferation. It features conserved kringle domains 1-4 with disulfide bond-stabilized tertiary structures, a heparin-binding region, and structural motifs critical for ligand interaction and biological activity. It localizes to rat plasma, extracellular matrices and tumor microenvironments, with negligible levels in healthy avascular tissues. The protein mediates endothelial cell migration suppression and angiogenesis inhibition, with conserved binding sites for integrins and matrix metalloproteinases. Rat ANG shares core functional domains with mammalian orthologs, and has distinct anti-angiogenic potency differentiating it from endostatin and thrombospondin-1.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.