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Rabbit Anti-Rat Alkaline Phosphatase (ALPP) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat alkaline phosphatase, placental. It is purified by protein A/G. It can be applied to WB assays of rat alkaline phosphatase, placental.
Specifications
Target Information
Rat placental alkaline phosphatase (ALPP) is a 524-residue, glycosyl-phosphatidylinositol-anchored ectoenzyme whose extracellular domain contains two zinc ions and one magnesium ion coordinated within the characteristic D/SxDxGxGxGxxD motif, enabling selective hydrolysis of phosphate monoesters at alkaline pH. The protein is tethered to the apical brush border of syncytiotrophoblasts and released as a 140 kDa homodimer after GPI cleavage. Expressed almost exclusively in placenta and at low levels in uterus, ALPP localizes to microvilli and maternal-facing membranes. Antibodies raised against the catalytic or GPI-anchor proximal peptide detect native, glycosylated and secreted dimers with negligible cross-reactivity to intestinal or bone alkaline phosphatase isoforms, enabling selective immunoblot and immunohistochemical visualization in rat placental homogenates and serum.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.