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Rabbit Anti-Mouse Transforming Growth Factor Beta Receptor II (TGFbR2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse transforming growth factor beta receptor II. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse transforming growth factor beta receptor II.
Specifications
Target Information
Mouse transforming growth factor beta receptor II (TGFβRII) is a 56-kDa transmembrane serine/threonine kinase ubiquitously expressed in murine tissues, with elevated levels in fibroblasts, epithelial cells, and immune cells. It forms heteromeric complexes with TGFβRI upon binding TGFβ ligands, activating SMAD-dependent and non-SMAD signaling pathways that regulate cell proliferation, differentiation, and extracellular matrix synthesis. Critical for murine embryonic development, tissue homeostasis, and immune suppression, it modulates wound healing and fibrosis. Dysregulated expression or mutations associate with cancer progression, fibrotic disorders (e.g., pulmonary fibrosis), and autoimmune diseases in mouse models. As a central mediator of TGFβ signaling, mouse TGFβRII is a critical target for studying tissue remodeling, tumorigenesis, and anti-fibrotic/anti-cancer therapeutics.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.