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Rabbit Anti-Mouse Topoisomerase II Beta (TOP2b) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse topoisomerase II beta. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse topoisomerase II beta.
Specifications
Target Information
Mouse Topoisomerase II Beta (TOP2B) is a nuclear enzyme that regulates DNA topology by transiently breaking and rejoining double strands, allowing transcription and replication machinery to proceed through templated DNA. It is expressed in neurons, muscle, and proliferating tissues, where it maintains chromatin architecture and supports immediate-early gene expression. TOP2B forms covalent cleavage complexes that are essential for strand passage yet reversible under normal conditions. Its activity safeguards genome integrity while enabling dynamic chromatin remodeling. Antibodies to TOP2B provide precise tools for mapping DNA relaxation events and chromatin-bound complexes in mouse models.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.