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Rabbit Anti-Mouse Sirtuin 2 (SIRT2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse sirtuin 2. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse sirtuin 2.
Specifications
Target Information
Mouse sirtuin 2 (SIRT2) is a 389-residue NAD⁺-dependent deacetylase of the sirtuin family, featuring a conserved catalytic Rossmann-fold domain that binds NAD⁺ and a smaller zinc-binding module recognizing acetyl-lysine substrates. Predominantly cytosolic, the enzyme associates with microtubules, centrosomes and oligodendrocyte cytoplasm during mitosis, adopting a cell-cycle-regulated expression peak in G2/M. Its N-terminal extension undergoes phosphorylation, modulating subcellular distribution between cytoplasm and nucleus. Antibodies directed against full-length or peptide epitopes of mouse SIRT2 detect both native and post-translationally modified isoforms with negligible cross-reactivity to SIRT1, SIRT3 or other sirtuins, enabling accurate immunoblot and immunofluorescence analysis in tissue homogenates and cultured cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.