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Rabbit Anti-Mouse Signal Transducing Adaptor Molecule 1 (STAM1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse signal transducing adaptor molecule 1. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse signal transducing adaptor molecule 1.
Specifications
Target Information
Mouse signal-transducing adaptor molecule 1 (STAM1) is a 540-residue cytosolic scaffold built from an N-terminal VHS domain, a central SH3 module, and a C-terminal ITAM motif that becomes tyrosine-phosphorylated upon cytokine triggering. The protein constitutively localizes to early endosomes via its coiled-coil region, where it assembles with Hrs and eps15 into ESCRT-0-like complexes. Expressed ubiquitously in spleen, thymus and brain, STAM1 cycles between cytosol and clathrin-coated pits. Antibodies raised against the SH3-ITAM linker or full-length recombinant protein detect native, phosphorylated and ubiquitinated isoforms with negligible cross-reactivity to STAM2 or other adaptors, enabling selective immunoblot and immunofluorescence analysis in mouse tissue homogenates and cultured cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.