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Rabbit Anti-Mouse Signal Regulatory Protein Alpha (SIRPa) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse signal regulatory protein alpha. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse signal regulatory protein alpha.
Specifications
Target Information
Mouse signal regulatory protein alpha (SIRPα) is a transmembrane glycoprotein of the immunoglobulin superfamily, a core regulator of immune cell activation and phagocytosis. It features three conserved extracellular Ig-like domains for ligand binding, a single transmembrane segment, and a cytoplasmic tail with immunoreceptor tyrosine-based inhibitory motifs (ITIMs) critical for signaling. It localizes predominantly to the plasma membrane of mouse macrophages, dendritic cells and neurons, with negligible expression in epithelial and erythroid cells. The protein mediates cell-cell interaction via binding to its ligand CD47, with conserved motifs for modulating downstream inhibitory signaling cascades. Mouse SIRPα shares core functional domains with mammalian orthologs, and has distinct regulatory specificity differentiating it from SIRPβ and SIRPγ.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.