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Rabbit Anti-Mouse Sclerostin (SOST) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse sclerostin. It is purified by Protein A Purified . It can be applied to WB, IHC, ICC and IP assays of mouse sclerostin.
Specifications
Target Information
Mouse Sclerostin is a secreted protein that plays a crucial role in bone remodeling and homeostasis. It is primarily produced by osteocytes and acts as a negative regulator of bone formation by inhibiting the Wnt/β-catenin signaling pathway. Sclerostin binds to LRP5/6 coreceptors, preventing Wnt ligands from activating downstream signaling, thereby suppressing osteoblast differentiation and function. Its expression is regulated by mechanical loading and hormonal signals. Sclerostin is an important target for studying bone biology and developing therapeutic strategies for osteoporosis and other skeletal disorders in mouse models.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.