This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Rabbit Anti-Mouse Prothrombin Fragment 1+2 (F1+2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse prothrombin fragment 1+2. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse prothrombin fragment 1+2.
Specifications
Target Information
Mouse prothrombin fragment 1+2 (F1+2) is the 156-residue activation peptide released upon factor Xa-mediated cleavage of prothrombin at Arg271-Thr272. The fragment comprises the Gla-rich module (residues 1-46) and two kringle domains that together bind calcium and phospholipid, forming a 35 kDa species that circulates transiently before degradation. Constitutively present at low picomolar levels, F1+2 localizes to plasma and thrombin-generating surfaces. Antibodies raised against the Gla-kringle linker or kringle-2 epitope detect native, calcium-bound and proteolyzed forms with negligible cross-reactivity to intact prothrombin or thrombin, enabling selective immunoblot and ELISA quantification in mouse plasma and tissue extracts.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.