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Rabbit Anti-Mouse Protease Serine 2 (PRSS2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse protease serine 2. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse protease serine 2.
Specifications
Target Information
Mouse protease, serine 2 (Prss2, trypsin-2) is a 25 kDa secreted serine protease whose N-terminal activation peptide is cleaved to expose a canonical catalytic triad (His-Asp-Ser) that hydrolyzes Lys/Arg C-terminal bonds. A solvent-exposed 12-residue "TNS" surface loop (aa 187-198) bordering the S1 pocket adopts a strain-unique β-bulge, presenting a conformational epitope preserved in both zymogen and mature forms. Affinity-purified antibodies targeting this loop trace native Prss2 in pancreatic acinar granules, intestinal lumen, and serum, delivering crisp apical staining and single-band clarity on immunoblots with no cross-reaction to Prss1 or other serine proteases.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.