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Rabbit Anti-Mouse Probable ATP-dependent RNA Helicase DDX58 (DDX58) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse probable ATP-dependent RNA helicase DDX58. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse probable ATP-dependent RNA helicase DDX58.
Specifications
Target Information
Mouse probable ATP-dependent RNA helicase DDX58-commonly known as RIG-I-scans the cytoplasm for viral RNA bearing 5'-triphosphate blunt ends or short double-stranded motifs. Binding to these non-self RNAs triggers ATP-driven conformational changes that expose its tandem CARD domains, enabling docking with mitochondrial MAVS and initiation of type-I interferon signaling. The helicase core (aa 229-662) provides a unique, pathogen-associated epitope ideal for antibody development; anti-DDX58 clones therefore visualize viral sensor activation in situ without interference from related helicases .
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.