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Rabbit Anti-Mouse Pim-1 Oncogene (PIM1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse pim-1 oncogene. It is affinity purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse pim-1 oncogene.
Specifications
Target Information
Mouse PIM1 is a serine/threonine kinase that plays a critical role in cell survival and proliferation. It regulates multiple cellular functions, including cell cycle progression and apoptosis. PIM1 promotes cell survival by phosphorylating and inactivating pro-apoptotic proteins such as BAD and MAP3K5, and it enhances cell proliferation by stabilizing MYC and regulating its transcriptional activity. Additionally, PIM1 is involved in mitochondrial integrity and has been implicated in drug resistance mechanisms.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 2 years). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Hu, Xiu Feng, et al. "PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis." The Journal of clinical investigation 119.2 (2009): 362-375.