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Rabbit Anti-Mouse Paxillin (PXN) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse paxillin. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse paxillin.
Specifications
Target Information
Mouse paxillin is a 559-residue cytoskeletal adaptor built from an N-terminal polyproline stretch, five tandem LD motifs that dock integrin-linked kinase and focal adhesion kinase, followed by four cysteine-rich LIM domains that anchor to actin and vinculin. Phosphorylatable tyrosines at residues 31 and 118 create tandem SH2-binding sites upon Src-family kinase engagement. Constitutively expressed in fibroblasts, epithelia and smooth muscle, paxillin localizes to focal adhesions, costameres and podosomes. Polyclonal and monoclonal antibodies raised against full-length or peptide epitopes detect both native and phosphorylated isoforms with negligible cross-reactivity to Hic-5 or leupaxin, enabling precise immunoblot and immunofluorescence analysis in mouse tissue extracts and cultured cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.