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Rabbit Anti-Mouse NLR Family Pyrin Domain Containing Protein 3 (NLRP3) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse NLR family pyrin domain containing protein 3. It is purified by protein A/G. It can be applied to WB assays of mouse NLR family pyrin domain containing protein 3.
Specifications
Target Information
Mouse NLR family, pyrin domain containing protein 3 (NLRP3) is an intracellular pattern recognition receptor of the NLR superfamily. It features a conserved N-terminal pyrin domain, a central nucleotide-binding and oligomerization domain (NOD), and a C-terminal leucine-rich repeat (LRR) region critical for structural integrity. It localizes to cytoplasm and endosomal membranes, with tissue-specific expression in mouse macrophages, neutrophils and dendritic cells, with negligible levels in non-immune tissues. The protein mediates inflammasome assembly and signal transduction, with conserved motifs for protein-protein interaction. Mouse NLRP3 shares core functional domains with mammalian orthologs, and has distinct ligand specificity differentiating it from NLRP1 and NLRP6.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.