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Rabbit Anti-Mouse Nischarin (NISCH) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse nischarin. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse nischarin.
Specifications
Target Information
Mouse nischarin is a 1,657-residue scaffold protein built from an N-terminal LIM domain, five PDZ modules, a coiled-coil region and a C-terminal alpha-helical segment that collectively mediate binding to integrin α5, PAK1 and the exocyst complex. Predominantly cytosolic, the polypeptide localizes to focal adhesions, lamellipodia and early endosomes in epithelial and vascular smooth-muscle cells. Alternative splicing introduces a 33-residue insert between PDZ3 and PDZ4, generating tissue-specific isoforms of 1657 and 1624 amino acids. Antibodies raised against the unique linker or full-length recombinant nischarin recognize native, phosphorylated and splice-variant forms with negligible cross-reactivity to other LIM/PDz proteins, enabling precise immunoblot and immunofluorescence detection in mouse tissue homogenates and cultured cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.