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Rabbit Anti-Mouse Neurokinin B (NKB) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse neurokinin B. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse neurokinin B.
Specifications
Target Information
Mouse neurokinin B (NKB) is a ten-amino-acid, C-terminally amidated peptide (Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH₂) derived by proteolytic cleavage from the 121-residue preprotachykinin B precursor. The peptide adopts an extended backbone conformation stabilized by hydrophobic stacking of aromatic residues 5-7 and a C-terminal methioninamide that confers high affinity for neurokinin 3 receptor. Expressed selectively in hypothalamic arcuate neurons and spinal cord interneurons, NKB is packaged into dense-core vesicles and co-released with kisspeptin. Antibodies raised against the full decapeptide or amidated C-terminal fragment detect native amidated NKB with negligible cross-reactivity to substance P or neurokinin A, enabling precise immunohistochemical and immunoblot visualization in mouse brain extracts and tissue sections.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.