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Rabbit Anti-Mouse Legumain (LGMN) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse legumain. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse legumain.
Specifications
Target Information
Mouse legumain (LGMN) is a 46-kDa cysteine protease predominantly expressed in murine lysosomes, with elevated levels in immune cells (macrophages, dendritic cells) and tumor tissues. It functions as an asparaginyl endopeptidase, mediating protein degradation, antigen processing for MHC class II presentation, and extracellular matrix remodeling. Critical for murine immune response regulation, tissue repair, and embryonic development, it also promotes tumor invasion and metastasis in cancer models. Dysregulated activity associates with inflammatory diseases, neurodegeneration, and malignant progression. As a key mediator of proteolytic signaling and immune modulation, mouse LGMN is a critical target for studying immunobiology, cancer pathobiology, and protease-targeted therapeutics.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.