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Rabbit Anti-Mouse Kelch Like ECH Associated Protein 1 (KEAP1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse kelch like ech associated protein 1. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse kelch like ech associated protein 1.
Specifications
Target Information
Mouse Kelch-like ECH-associated protein 1 (Keap1) is a 624-residue cytosolic repressor built from an N-terminal BTB domain that mediates Cul3 ubiquitin ligase binding, a central intervening region rich in reactive cysteines, and a C-terminal Kelch repeat propeller providing two binding pockets for the DLG and ETGE motifs of Nrf2. The dimeric scaffold adopts a cherry-bob conformation, positioning substrate and ubiquitin machinery 20 Å apart. Constitutively expressed in liver, kidney and airway epithelium, Keap1 localizes to perinuclear actin and focal adhesions. Antibodies raised against full-length or Kelch-specific peptides detect native, phosphorylated and oxidized forms with negligible cross-reactivity to other BTB-Kelch proteins, enabling selective immunoblot and immunofluorescence detection in mouse tissue and cultured cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.