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Rabbit Anti-Mouse Katanin P60 Subunit A 1 (KATNA1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse katanin P60 subunit A 1. It is purified by protein A/G. It can be applied to WB and IHC assays of mouse katanin P60 subunit A 1.
Specifications
Target Information
Mouse katanin p60 subunit A 1 (KATNA1) is the catalytic core of the katanin microtubule-severing complex, a key regulator of microtubule dynamics and cytoskeletal remodeling. It features a conserved N-terminal ATPase domain critical for hydrolyzing ATP to drive microtubule cleavage, a central microtubule-binding region, and a C-terminal domain for assembling with regulatory subunits. It localizes predominantly to the cytoplasm and centrosomes of mouse dividing cells, neurons and epithelial cells, with negligible expression in quiescent cell populations. The protein mediates microtubule severing via ATP-dependent conformational changes, with conserved structural motifs differentiating it from other microtubule-associated proteins.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.