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Rabbit Anti-Mouse Interleukin 12 Receptor Beta 1 (IL12Rb1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse interleukin 12 receptor beta 1. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse interleukin 12 receptor beta 1.
Specifications
Target Information
Mouse interleukin 12 receptor beta 1 (IL-12Rβ1) is a transmembrane glycoprotein encoded by the Il12rb1 gene in Mus musculus, mapped to chromosome 7. It belongs to the class I cytokine receptor family, featuring conserved extracellular fibronectin type-III domains, a single transmembrane segment and an intracellular domain critical for signal propagation. It localizes to cell membrane, with tissue-specific expression in mouse T lymphocytes, natural killer cells and macrophages, with minimal levels in non-immune tissues. The protein forms heterodimeric receptor complexes, with conserved motifs for ligand binding and structural stability. Mouse IL-12Rβ1 shares core functional domains with mammalian orthologs, and has distinct binding specificity differentiating it from IL-12Rβ2 and other cytokine receptors.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.