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Rabbit Anti-Mouse Guanidinoacetate-N-Methyltransferase (GAMT) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse guanidinoacetate-N-methyltransferase. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse guanidinoacetate-N-methyltransferase.
Specifications
Target Information
Mouse guanidinoacetate-N-methyltransferase (GAMT) is a cytosolic methyltransferase with a conserved S-adenosyl-L-methionine (SAM)-binding domain, a core mediator of creatine biosynthesis. It features an N-terminal catalytic region critical for methyl group transfer, a central substrate-binding motif for guanidinoacetate recognition, and a C-terminal domain for structural stability. It localizes predominantly to the cytoplasm of mouse hepatocytes and renal tubular cells, with negligible expression in muscle or neuronal tissues. The protein mediates the key methylation step in creatine production, with conserved structural elements differentiating it from other SAM-dependent methyltransferases.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.