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Rabbit Anti-Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse glutamate cysteine ligase, catalytic. It is purified by Protein A Purified . It can be applied to WB, IHC, ICC and IP assays of mouse glutamate cysteine ligase, catalytic.
Specifications
Target Information
Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) is a crucial enzyme in the synthesis of glutathione, a major antioxidant in cells. It catalyzes the rate-limiting step in glutathione production, forming the intermediate γ-glutamylcysteine. GCLC is expressed in various tissues and plays a vital role in protecting cells from oxidative damage by maintaining glutathione levels. Its activity is essential for cellular redox homeostasis and detoxification processes. GCLC is an important target for studying antioxidant defense mechanisms and oxidative stress-related diseases in mouse models.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Chen, Ying, et al. "Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels." Journal of Biological Chemistry 280.40 (2005): 33766-33774.